Tuesday, August 28, 2012

Study questions recommendation to discontinue LABA therapy in asthma patients

ScienceDaily (Aug. 27, 2012) ? An extensive literature review and analysis of five clinical trials suggests that discontinuing long-acting ?2-agonist (LABA) therapy in adults and older children who have asthma that is controlled with a combination of inhaled corticosteroids and LABAs may be associated with increased asthma-related impairment, according to a report published in Online First by Archives of Internal Medicine, a JAMA Network publication released Aug. 27.

Thomas Casale, M.D., professor of medicine and chief of Allergy/Immunology, Creighton University, served as a primary author of the paper. Currently the U.S. Food and Drug Administration recommends that once asthma is controlled, LABA be withdrawn because of safety concerns.

"Our evidence suggests that such an action could result in increased asthma-associated impairment. At a minimum there is a lack of studies evaluating the issue," said Casale.

A LABA step-off regimen appeared to increase asthma impairment, with worse Asthma Quality of Life Questionnaire scores; worse Asthma Control Questionnaire scores; and fewer symptom-free days, according to study results.

Authors recognize that there is a FDA mandate for LABA safety studies by manufacturers of these agents but results won't be available for about five years.

"Our analysis supports the positive effects of LABAs for achieving and maintaining asthma control," Casale added.

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Story Source:

The above story is reprinted from materials provided by Creighton University, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jan L. Brozek et al. Long-Acting ?2-Agonist Step-off in Patients With Controlled Asthma. Arch Intern Med., August 27, 2012 DOI: 10.1001/archinternmed.2012.3250

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/WiBOys3TQ08/120827151623.htm

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Ashwin hopes India continues winning performance

Hyderabad, Aug 26

Ravichandran Ashwin is pleased over India starting the season with a victory against New Zealand in the first cricket Test and hopes the team would continue to perform in the same vein.

Aswhin, who was Man-of-the-Match for his 12/85, noted that the team had a tough last year.

"As a whole the team had a tough year but it happens with every team. We have put that behind. We are starting on a good note, hoping to continue and have a great season," he said after India defeated New Zealand by an innings and 115 runs here Sunday.

He said he was happy to have the best figures by any Indian bowler against the Kiwis.

"I don't get too bogged down with individual performances even if it is great or even if it is bad. It's a good start. The pressure is off my bag. I can enjoy myself and just let the ball do the talking, just look at various things that I have to be working on constantly."

The off-spinner pointed out that when New Zealand toured India last time they batted well and almost drew the series. "As this is not a venue where we won the last time so we came with a lot of apprehensions but at the end of the day I think we did very well as a unit to win the test match in four days."

Ashwin believes the contest in the second test at Bangalore would be stiffer as the Kiwi batsmen would come up with better plans.

He said the wicket at Hyderabad was very good. "I enjoyed the wicket a lot. There was enough in it for the bowlers and it was a very good batting wicket as well," he added.

He said Indian bowlers stuck to their basics when McCullum and Williamson were batting.

"We realised that we had to stick to our basics. We have to take one wicket at a time. When two batsmen are going good, it becomes tough for bowlers to dislodge them. You have to be patient. Once that one or two wickets fall it becomes much more easier because the new batsman has to move his feet around, put his technique in place. You can be really attacking at that point of time," he said as New Zealand were bowled out for 164 in the second innings from 98 for one.

Ashwin described Jeetan Patel's first innings dismissal and Ross Taylor's second inning dismissal as his best.

"It happened in first class match of my career. I don't remember after that," he said when asked about New Zealand captain's dismissal in second innings. Taylor was clean bowled when he left a ball which spun in and uprooted the bails.

Source: http://www.prokerala.com/news/articles/a323394.html

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Racial Disparities In Prostate Cancer Care - Cancer - eWallstreeter


From: Prostate / Prostate Cancer News From Medical News Today - 3:00am - August 27, 2012

A study led by investigators from Vanderbilt-Ingram Cancer Center (VICC), Nashville, Tenn., finds that black men with prostate cancer receive lower quality surgical care than white men. The racial differences persist even when controlling for factors such as the year of surgery, age, comorbidities and insurance status. Daniel Barocas, M.D...

Continue reading this article ?

Source: http://ewallstreeter.com/racial-disparities-in-prostate-cancer-care-3901/

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Monday, August 27, 2012

Solid State Quantum Computer Finds 15=3x5 — 48% of the Time

Nah, as others have pointed out, what you do is run the Shor's algorithm, then verify it. If it's wrong, run Shor's again. If it's right, you know you have the factorization. In this way, you can be 100% sure that you've correctly solved the problem, even if Shor's only provides the correct answer some percentage of the time.

What I don't fully understand is why 48% makes this impractical. Having not read TFA, the only way I can imagine that would be the case is if somehow not having exactly a 50% chance

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/vQ0Lm0gaNBw/solid-state-quantum-computer-finds-153x5-48-of-the-time

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Isaac threatens to overshadow U.S. Republican convention

TAMPA (Reuters) - Tropical Storm Isaac menaced the U.S. presidential election campaign on Sunday, forcing Republicans to make changes to their national convention in Tampa, Florida, where party officials scrambled to make sure candidate Mitt Romney's message to voters does not get blown off course.

The storm was now forecast to hit land midweek, possibly even blasting into New Orleans at hurricane strength on the seventh anniversary of Hurricane Katrina - which might hurt the party's effort to get out its message more than if it had hit Tampa Bay directly as originally predicted.

Expecting earlier that Tampa would be in Issac's sights, convention organizers had canceled Monday's opening events and tried to squeeze as many speakers and activities into three days as had been planned for four.

Republicans this week are to formally nominate Romney and vice presidential running mate Paul Ryan as their candidates to face President Barack Obama and Vice President Joe Biden in the November 6 election.

"It's a concern ... competing with a major weather event," Virginia Governor Bob McDonnell said on ABC's "This Week." Still he said he expected independent voters particularly will tune in to hear Romney and Ryan speak. "I think we'll still get a fair amount of attention, and the message will be good."

"We're going to tell the Mitt Romney story, we're still going to prosecute the president on what he promised, what he delivered, and why we think we need to save this country and put Mitt Romney in the White House," Republican National Committee Chairman Reince Priebus said on CNN.

The Republican convention, just like the Democrats' similar gathering in Charlotte, North Carolina, early next month, is typically a celebratory event bringing together thousands of party activists from across the United States for a week of speeches, partying and strategizing.

But the Republicans, now faced with a potential natural disaster along the same Gulf Coast that saw 1,800 people killed and billions of dollars in damage from Hurricane Katrina on August 29, 2005, will have to temper any celebrations with concern for those affected by Isaac.

The importance of the convention for Romney cannot be overstated. Running either even with Obama or slightly behind him, Romney needs a bounce in the polls from the convention.

His challenge is to convince Americans that he is a viable alternative to the incumbent Democrat, and his big week, culminating with a speech on Thursday, needs as few distractions as possible. Media focused on howling winds and storm surges in another part of the country will make his task more difficult.

He enters convention week having made a self-inflicted error by telling a crowd in Michigan "no one's ever asked to see my birth certificate," a joke that rekindled a storyline from conservatives over whether Obama was actually born in the United States.

Romney tried to get the focus on what he considers the paramount issue in the campaign, the weak U.S. economy, telling Fox News he and Ryan would offer "big and bold answers."

"America needs that kind of help at a time when so many people are out of work or underemployed or having a hard time making ends meet," he said in remarks broadcast on Sunday.

Fueled by warm Gulf waters, Isaac is expected to strengthen into a Category 2 hurricane with 105 mph winds and landfall was likely to come midweek somewhere between Florida and Louisiana, the Miami-based National Hurricane Center said.

The storm expected to be at or near hurricane force when it swept across the Florida Keys by Sunday evening, the NHC said. A storm becomes a hurricane when sustained winds reach a minimum of 74 miles per hour. At least six people were killed when it moved across Haiti.

SAFETY FIRST

Party officials were working with Florida state officials and emergency management to ensure the safety of everyone attending the convention. Although it may move ashore to the west, heavy winds and rain can stretch hundreds of miles out from the storm's center.

A Lynyrd Skynyrd concert planned for Sunday night was canceled due to the likely severe weather, although performances by Trace Adkins, Kid Rock and Journey were moving ahead as scheduled.

The Republican convention will bring 50,000 visitors to the Tampa-St. Petersburg area, home to well over 4 million people. Over the last few days, local authorities have said they could handle the crowds and the approaching storm.

Many attendees booked earlier flights to be in place before any bad weather. Hotels said they were ready to shift party schedules or move outdoor events indoors.

The last Republican convention, in St. Paul, Minnesota, in 2008 was also delayed a day due to a storm. That year, Hurricane Gustav hit the Louisiana coast as the convention was set to nominate Senator John McCain as the Republican nominee.

The party, still reeling from criticism of Republican President George W. Bush's handling of devastating Hurricane Katrina in 2005, rushed to delay the meeting out of respect for Gustav's victims.

Convention president Bill Harris said the party was ready operationally for events in Tampa to begin but they were acting out of an "abundance of caution" because of the uncertainty of the weather.

"I want to make sure everyone who attends the convention is safe and everyone who lives in Florida is not unnecessarily injured by any activities taking place when a storm threatens," Harris said.

Biden, who had planned to visit Florida during the convention but who had already canceled his Tampa event because of the storm has decided to also cancel his other events in Orlando and St. Augustine.

(This story is corrected to Governor McDonnell in paragraph 5 from RNC Chairman Priebus)

(Additional reporting by Deborah Charles; Editing by Jackie Frank)

Source: http://news.yahoo.com/isaac-disrupts-presidential-election-campaign-050649297.html

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RPG Newbie (it rhymes!)

Howdy all!

So, I'm new to this community. My RP background is mostly old AOL related though I figure I'll attempt to transition to a new medium. I do miss my role plays!

Regarding my availability, honestly, I'm not sure what it'll be these days as I'm switching to a new job shortly that, I believe, is going to offer me much better flexibility than my old one. We can discuss times though!

And then, finally, my interests.
- Final Fantasy-related (that is, borrow the setting, play original characters :D)
- Medieval/Fantasy
- Pretty much any time period with some non-ordinary details added to it!

So, uh, yeah! That's that!

NLV (the name is phonetic for my old tag. xD)

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/u654svMT3Y8/viewtopic.php

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Refinery blast kills 24 in Venezuela, 86 hurt

CARACAS, Venezuela (AP) ? A huge explosion rocked Venezuela's biggest oil refinery and unleashed a ferocious fire Saturday, killing at least 24 people and injuring more than 80 others in the deadliest disaster in memory for the country's key oil industry.

Balls of fire rose over the Amuay refinery, one of the largest in the world, in video posted on the Internet by people who were nearby at the time. Government officials pledged to restart the refinery within two days and said the country has plenty of fuel supplies on hand to meet its domestic needs as well as its export commitments.

At least 86 people were injured, nine of them seriously, Health Minister Eugenia Sader said at a hospital where the wounded were taken. She said 77 people suffered light injuries and were released from the hospital.

Officials said those killed included a 10-year-old boy, but that most of the victims were National Guard troops stationed at the refinery.

Vice President Elias Jaua, who traveled to the area in western Venezuela, said the authorities were "trying to save the greatest number of lives."

Officials said firefighters had controlled the flames at the refinery on the Paraguana Peninsula, where clouds of dark smoke were billowing at daybreak.

Oil Minister Rafael Ramirez said the state oil company should be able to "restart operations in a maximum of two days."

"We have sufficient supplies... in the entire country, and our production at the maximum to deal with any situation in our domestic market," Ramirez said. "In that sense, we won't have major effects."

An official of the state oil company, Petroleos de Venezuela SA, said the country also has enough supplies on hand to guarantee its international supply commitments. The official spoke on condition of anonymity because he wasn't authorized to speak publicly about the matter.

The blast occurred about 1:15 a.m. when a gas leak created a cloud that ignited, Ramirez said. An adjacent National Guard post was severely damaged by the blast, he said.

"That gas generated a cloud that later exploded and has caused fires in at least two tanks of the refinery and surrounding areas," Ramirez said. "The blast wave was of a significant magnitude."

Images in the early hours after the explosion showed the flames casting an orange glow against the night sky. One photograph showed an injured man being wheeled away on a stretcher.

"The areas that had to be evacuated were evacuated," Falcon state Gov. Stella Lugo said on television, according to the state-run Venezuelan News Agency. "The situation is controlled. Of course there's still a fire rising very high, but ... the specialists tell me there is no risk of another explosion."

Ramirez said a panel of investigators was being formed to investigate the cause of the gas leak. A prosecutor also was assigned to lead the investigation. Troops were deployed to the area.

Ramirez said that nine storage tanks were damaged. He said supplies of fuel had been cut off to part of the refinery, and that the fire had been brought under control, though the flames would continue to burn up fuel in some of the tanks.

"At this time, the situation is controlled," Jaua said on television, while smoke continued to billow from the refinery.

Amuay is part of the Paraguana Refinery Complex, which also includes the adjacent Cardon refinery. Together, the two refineries process about 900,000 barrels of crude per day and 200,000 barrels of gasoline. Venezuela is a major supplier of oil to the U.S. and a member of the Organization of Petroleum Exporting Countries.

While the cause of Saturday's disaster remained unclear, some critics of President Hugo Chavez's government have recently pointed to increasing numbers of smaller accidents and spills as an indication of problems within the state-run company known as PDVSA.

"This tragedy is probably the worst one the oil industry has had in many years. Accidents happen, of course, although the problem with PDVSA is the inordinate amount of accidents that have taken place during the last years," said Gustavo Coronel, an energy consultant and former executive of PDVSA. Considering that record overall, Coronel said, "we are not talking about bad luck but about lack of maintenance and inept management."

Deadly accidents also occurred in Venezuela's oil and natural gas industry in the past. In 1993, a natural gas pipeline exploded beneath highway in Las Tejerias, engulfing a passenger bus and cars. Officials said 36 people were killed.

On Saturday morning, Ramirez said the explosion occurred in an area of the refinery where storage tanks are located. On television, he showed an aerial map of the rows of tanks where the flames raged.

"All of the events happened very quickly," he said. "When we got here in the middle of the night, at 3 or 3:30 in the morning, the fire was at its peak."

_____

Associated Press writers Jorge Rueda and Fabiola Sanchez contributed to this report.

Source: http://news.yahoo.com/refinery-blast-kills-24-venezuela-86-hurt-165431537--finance.html

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